The Reptile Expo is held at the Suffolk Community College in Brentwood. The closest hotel is the Upsky Long Island Hotel, 110 Venderbilt Motor Parkway in Hauppauge. This is less than a 1/2 mile from the expo location, just off of same Long Island Expressway exit 53. A limited number of discounted rooms are being offered for the expo-but to receive the discounted expo rate you do need to book at least 30 days ahead- be sure to book early! The hotel number is 631-231-1100. They are ok with discretely packaged herps.
There is also a Holiday Inn Express a couple of miles away. Their number is: 631-348-1400.